Circulating Tumor Cell (CTC) Imaging After Microfluidic Enrichment
Improve the recovery and characterization of rare circulating tumor cells (CTCs) with SmartBioSurface® slides following enrichment with the Parsortix® system (CelLBx Health), a microfluidic platform that efficiently isolates CTCs from whole blood based on their physical properties, including size and deformability, independently of epithelial marker expression.
As CTCs are exceptionally rare and fragile, maximizing cell retention while preserving morphology is essential for obtaining reliable and meaningful results. SmartBioSurface slides provide stable adhesion of Parsortix-enriched CTCs throughout fixation and immunofluorescence staining workflows, helping to minimize the cell loss often associated with conventional slide preparation methods.
The nanostructured titanium coating combines efficient cell immobilization with low background fluorescence, enabling clear visualization of tumor cells even within complex cellular backgrounds. This makes SmartBioSurface slides particularly well suited for downstream fluorescence imaging and phenotypic characterization of CTCs isolated using the Parsortix system.
Fully compatible with high-resolution fluorescence and confocal microscopy, SmartBioSurface slides offer a simple and reliable workflow for the analysis of enriched CTC samples. By preserving cell integrity and enhancing imaging performance after Parsortix enrichment, they provide researchers with a powerful solution for liquid biopsy applications, cancer research, and translational oncology.
